De Soto County, MS - Population Estimate, Total, Not Hispanic or Latino, American Indian and Alaska Native Alone (5-year estimate) in DeSoto County, MS was 246.00000 Persons in January of 2022, according to the United States Federal Reserve. Historically, De Soto County, MS - Population Estimate, Total, Not Hispanic or Latino, American Indian and Alaska Native Alone (5-year estimate) in DeSoto County, MS reached a record high of 515.00000 in January of 2010 and a record low of 135.00000 in January of 2015. Trading Economics provides the current actual value, an historical data chart and related indicators for De Soto County, MS - Population Estimate, Total, Not Hispanic or Latino, American Indian and Alaska Native Alone (5-year estimate) in DeSoto County, MS - last updated from the United States Federal Reserve on June of 2024.